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Phase I breaks it down into metabolites, some of which are reactive and potentially harmful
Emerging evidence reported the role of glutamine mediating reductive carboxylation for lipid biosynthesis and also for redox homeostasis in cancer with dysfunctional mitochondria or under hypoxia [34,41-43]
Treatment of HepG2 cells with different concentrations of NFT or DEM for 24 h led to a concentration-dependent increase in Nrf2 and GCLC protein levels, whereas no significant change was observed in the levels of the modifier subunit, GCLM (Fig
also identified as G6PDH)
Cisplatin and carboplatin, two platinum-based chemotherapeutic agents, have similar efficacy profiles, with carboplatin exhibiting reduced toxicity compared with cisplatin
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